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pentobarbital decreases levels of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can reduce panobinostat levels by ~70% and result in cure failure.Phenobarbital has actually been proven to shorten the 50 %-lifetime of doxycycline for as long as 2 months soon after barbiturate therapy